From Pharmacy Drug Guide
Cymbalta® side effects include nausea, dry mouth, sleepiness, fatigue, constipation, dizziness, decreased appetite, and increased sweating. Cymbalta® raises levels of the neurotransmitters serotonin and norepinephrine in the brain. Studies have shown that in rare cases, youths up 24 years of age may develop suicidal tendencies while taking Cymbalta®.
Cymbalta® is a prescription medication used to combat depression and Generalized Anxiety Disorder (GAD) - a condition characterized by excessive worry and tension that can interfere with everyday activities and lasts for half a year or more. Cymbalta® also treats pain and tingling caused by diabetic nerve damage and fibromyalgia. In addition, the drug is used to treat ongoing bone or muscle pain like lower back pain or osteoarthritis.
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|Brand name for||Duloxetine|
|Manufacturer||Lilly USA, LLC|
|Uses||Treatment of major depressive disorder and generalized anxiety disorder; management of diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain due to chronic osteoarthritis pain and chronic low back pain.|
|Common side effects||Nausea, dry mouth, sleepiness, fatigue, constipation, dizziness, decreased appetite, and increased sweating|
|Who should not take Cymbalta®?||People who have recently taken a type of antidepressant called monoamine oxidase inhibitors (MAOIs) or Mellaril® (thioridazine) or who have uncontrolled narrow-angle glaucoma (increased eye pressure).|
|Disclaimer||The information provided by PharmacyDrugGuide is not a substitute for professional medical advice, diagnosis, or treatment. Do not take any action based on the information on this page without consulting a physician.|
Common Cymbalta Side Effects
The most commonly reported side effects of Cymbalta® include upset stomach, dry mouth, drowsiness, issues with bowel regularity or diarrhea, acid reflux, more frequent urination, difficulty urinating, increased perspiration, lowered appetite, cramping in the muscles, sexual dysfunction, and shakiness. Cymbalta® can also cause serious side effects such as liver damage, abnormal bleeding, and mania. Some patients who take Cymbalta® may develop a condition called Serotonin Syndrome that can be life-threatening.
About Drug Side Effects
Cymbalta Allergic Reactions
Cymbalta® can cause a form of Erythema multiforme called Stevens-Johnson syndrome, which is characterized by fever, itching of the skin, joint pain, and multiple skin lesions. The lesions may resemble hives, but may also appear as nodules or a sore surrounded by bulls-eye rings. Stevens-Johnson syndrome can be fatal.  Other patients may develop Cymbalta® allergic symptoms such as skin rash, blisters, or sores inside the mouth.
Some patients have experienced side effects after discontinuing Cymbalta®. These withdrawal symptoms included mood changes, dizziness, nausea, headache, exhaustion, nerve pain, confusion, vomiting, nightmares, insomnia, diarrhea, anxiety, excessive sweating, vertigo, tinnitus, and seizures. To minimize SSRI withdrawal symptoms, Cymbalta® is generally discontinued gradually, with a physician tapering down the dosage over a period of several weeks. Some physicians will switch the patient from Cymbalta® to Prozac before beginning the taper, as Prozac has a longer half-life, making the effect on the brain more gradual.
Cymbalta Precautions and Warnings
- Taking Cymbalta® may cause sleepiness or dizziness. Activities that require concentration, such as operating a motor vehicle, may be dangerous for patients taking Cymbalta®.
- Increased risk of bleeding is possible among older patients who take Cymbalta®.
- Cymbalta® may cause hyponatremia, a salt imbalance, in older patients.
- There is a chance that Cymbalta® will affect blood sugar levels in diabetics.
- It is possible for infants born to Cymbalta® users to experience withdrawal from the drug. In addition, Cymbalta® will appear in breast milk of nursing mothers.
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