Lisinopril Side Effects

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Lisinopril is a long-acting angiotensin-converting enzyme (ACE) inhibitor, a prescription medication used to treat high blood pressure and to improve survival after a heart attack.[1] [2] While lisinopril helps to control hypertension and heart failure, it is not a cure.[3]

Some of the common side effects of lisinopril include cough, dizziness, headache, nausea, diarrhea, or a change in sexual ability. Allergic reactions are also possible, and patients who are allergic to other ACE inhibitors may be unable to take lisinopril.[3] Lisinopril can cause fetal harm to when used by women who are pregnant or who are planning to become pregnant.[3]


Brand name Prinivil®, Tensophil®, Zestril®, Prinzide®, Zestoretic®[3]
Manufacturer Merck, AstraZeneca
Uses Treating blood pressure, congestive heart failure, heart attack.[3]
Common side effects Cough, lightheadedness, dizziness, headache, sexual side effects, weakness[3]
Who should not take lisinopril? Patients who are allergic to other ACE inhibitors; children under six years of age; patients who are pregnant or who might become pregnant[2]
Disclaimer The information provided by is not a substitute for professional medical advice, diagnosis, or treatment. Do not take any action based on the information on this page without consulting a physician.
Author Susan MacDowell



About Lisinopril

Common Lisinopril Side Effects

Common side effects of lisinopril may include:

  • Cough
  • Runny nose or sneezing
  • Dizziness
  • Excessive tiredness or weakness
  • Headache
  • Nausea
  • Diarrhea
  • Decrease in sexual ability[3]
  • Fever, sore throat, chills, and other signs of infection
  • Chest pain
  • Lightheadedness or fainting
  • Yellowing of the skin or eyes[3]

About Drug Side Effects

An overview of common side effects of drugs like lisinopril

Lisinopril Allergic Reactions

Patients who are allergic to other ACE inhibitors (benazepril, cilazapril, delapril, fosinopril, pentopril, perindopril, quinapril, ramipril, trandolapril, moexipril, spirapril, temocapril and imidapril,) or to inactive ingredients in lisinopril tablets may be unable to take lisinopril.[3] [1] Symptoms of an allergic reaction which may require medical intervention include:

  • Swelling or angioedema of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • Hoarseness
  • Difficulty breathing or swallowing
  • Rash or hives
  • Abdominal pain[3] [2]

Lisinopril Precautions and Warnings

  • ACE inhibitors like lisinopril, when taken during the second and third trimesters of pregnancy, can cause injury or death to the fetus.[1]
  • Patients under the age of six should not take lisinopril.
  • Lisinopril may interact with diuretics (water pills), and dosages of lisinopril or the diuretic may need to be adjusted for patients who are taking them.
  • Lisinopril can react with aspirin, as well as other non-steroidal anti-inflammatory drugs (NSAIDs) like Advil®.
  • Antidiabetic medications may interact with lisinopril, especially in patients with a history of kidney problems, and especially in the first weeks of treatment.
  • Non-steroidal anti-inflammatory agents (NSAIDs), like ibuprofen (Advil®, Motrin®) may reduce the effect of lisinopril, and it may be necessary to adjust the dose of lisinopril.
  • Lisinopril may interact with lithium, and if taken together lithium levels should be monitored.[1]
  • Patients may experience a drop in blood pressure if they lose too much water from increased sweating, throwing up or diarrhea. This can cause lightheadedness, and even cause loss of consciousness in severe cases.[3]
  • Lisinopril may not be safe for patients with history of kidney disease, heart disease, lupus, angiodema, an illness that causes painful swelling of the facial areas or limbs, trouble breathing, and trouble swallowing.[3]


Also See: Lisinopril, Lisinopril Patient Assistance Programs, Lisinopril Coupons, Marijuana and High Blood Pressure, Altace Side Effects



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