Marijuana and Prozac

From Pharmacy Drug Guide

Jump to: navigation, search

Marijuana and Prozac® (fluoxetine) are contraindicated for simultaneous use. Although Prozac® can sometimes lead to an upset stomach and marijuana is sometimes used to treat nausea, the two drugs do not agree with one another.[1] In addition, Prozac® side effects and marijuana side effects may occur when taking these medications singularly.

Using marijuana and the antidepressant Prozac at the same time can result in a condition called hypomania. Hypomania is characterized by irritability, anxiety and feelings of jitteriness. Marijuana can also cause unpleasant or dangerous interactions with mixed with other prescription drugs, including sedative medicines and blood thinners. Patients are advised to consult their doctors or pharmacists about any potential reactions when using marijuana, Prozac®, or any other prescriptions.[2]


Flickr: Chuck “Caveman” Coker
Prozac is the brand name for Fluoxetine
Manufacturer Lilly
Introduced in 1986[3]
Uses Antidepressant, also treats panic disorder and bulimia
Dangers Mixing Prozac and marijuana can cause irritation and jitteriness [2]
Disclaimer The information provided by is not a substitute for professional medical advice, diagnosis, or treatment. Do not take any action based on the information on this page without consulting a physician.
Author Susan MacDowell


About Prozac

Prozac is the brand name for the drug fluoxetine hydrochloride. It is available with a prescription only, and is used to treat major depressive disorder, bulimia, panic disorder, and obsessive compulsive disorder (OCD). Other brand names for fluoxetine include Rapiflux® and Sarafem®. Prozac® is a selective serotonin reuptake inhibitor or SSRI, which means that it works by raising the levels of serotonin in the brain. It is administered orally. Prozac® can take anywhere from one to four weeks, or sometimes longer, to take effect.[1]

Side effects of Prozac® include decreased appetite, upset stomach, diarrhea, tiredness, excess perspiration, trembling, anxiety, hot flashes, strange dreams, and sexual side effects. Prozac® may cause increased thirst, frequent urination, nose bleeds and involuntary muscle movements in children and teens. In addition, there is a possibility that Prozac® may stunt growth in those who are not fully developed.[3]

About Marijuana

Marijuana is used for recreational purposes, and is often also recommended by doctors for various illnesses and conditions. It is the most widely used illegal drug in America, although there are some states in which it is legal for medical use. Marijuana comes from a plant called Cannabis sativa, which is in the hemp family. Cannabis contains high levels of a compound called Delta-9-tetrahydrocannabinol, or THC. The THC is what induces the psychedelic effects, and also gives marijuana its medicinal properties. The flowers and leaves of the Cannabis plant are dried to create marijuana, which may then be smoked or prepared into foods and eaten.[4]

Marijuana side effects can include reduced cognitive ability, bloodshot eyes, "cotton mouth," increased desire for food ("the munchies"), upset stomach, and sexual side effects. Marijuana users may experience lapses in memory, and learning aptitude may be impaired for a period of weeks after use.

Mixing Prozac with Marijuana

Doctors advise being cautious when combining marijuana with Prozac, as moderate-level reactions can occur. The primary concerns are mood changes such as nervousness and excitability, termed as hypomania.

Other drugs interact with marijuana, as well. Marijuana can cause major reactions when taken with sedatives like Ambien®, Klonipin®, and Ativan®, causing excessive drowsiness. Disulfiram (Antabuse®) and marijuana can cause insomnia and irritability, and blood thinners like warfarin (Coumadin®) may cause easier bruising when used with marijuana.[2]

Drug Side Effects

Common side effects of prescriptions like Prozac


Also See: Medical Marijuana, Marijuana Coupons, Marijuana and Pain, Marijuana and High Blood Pressure, Marijuana and Nausea, Marijuana Side Effects, Prozac Side Effects, Zoloft, Prozac and Pregnancy, Viibryd



  1. 1.0 1.1
  2. 2.0 2.1 2.2
  3. 3.0 3.1