Marijuana and Zoloft

From Pharmacy Drug Guide

Jump to: navigation, search

Combining marijuana and Zoloft® can create unwanted side effects. It is not safe to combine marijuana with any antidepressants, as doing so increases the risk of unsafe side effects. Marijuana is a mind-altering substance that has been used for centuries to get "high", as well as to treat a variety of medical conditions. Sixteen states in the U.S. permit marijuana use for eligible patients, but the drug is not legal for any purpose under federal law. Marijuana resembles tobacco, and is greenish-brown in color. Users most often smoke the drug, but may sometimes brew it in a tea or add it to other cooked foods.[1]

Flickr: The Equinest"
Zoloft® active ingredient Sertraline[2]
Manufacturer Pfizer[2]
Uses Antidepressant[2]
Common side effects Upset stomach, delayed ejaculation, shaking, perspiration, lower appetite, and sex drive[2]
Major side effects May cause increased suicide risk in young people[2]
Disclaimer The information provided by is not a substitute for professional medical advice, diagnosis, or treatment. Do not take any action based on the information on this page without consulting a physician.
Author Selena Robinson



About Zoloft

Zoloft® is a selective serotonin reuptake inhibitor (SSRI) prescribed to treat major depression as well as obsessive compulsive disorder (OCD), post-traumatic stress disorder (PTSD), social anxiety disorder, panic disorder, and other conditions. It elevates serotonin levels in the brain, positively affecting mood. Physicians often start patients on a low dose of Zoloft®, and then increase the amount over time. Patients may not experience the drug's full effects for weeks.[3]

Zoloft® can cause side effects such as constipation, upset stomach, bloating, reduced appetite, drowsiness, dizziness, headaches, tingling, shaking, soreness, and changes in sexual desire and function. In some cases, side effects can be serious or life threatening. Medical attention is necessary if patients experience symptoms like altered vision, seizures, flu symptoms, or strange bruising and bleeding. Zoloft® may not be safe for patients with a history of heart problems, liver disease, heart disease, or seizures. Zoloft® can cause complications when used during the final months of pregnancy.[3]

Side Effects of Drugs

Common side effects of prescription and nonprescription drugs

Marijuana and Zoloft

Although there is little research regarding the safety of mixing marijuana and Zoloft®, the side effects of both drugs are similar. Therefore, it can be harmful to take them at the same time. Doing so may increase the risk of anxiety, rapid heartbeat, confusion, panic, upset stomach, tiredness, and dizziness.[4]


Also See: Marijuana and Xanax, Zoloft Patient Assistance Programs, Zoloft Free Samples, Marijuana and Lexapro, Zoloft and Pregnancy



  2. 2.0 2.1 2.2 2.3 2.4
  3. 3.0 3.1