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Zoloft® (sertraline) is a prescription antidepressant in a class known as selective serotonin reuptake inhibitors (SSRIs). SSRIs work by increasing the amount of serotonin in the brain. Zoloft® is approved by the FDA for the treatment of major depression, obsessive-compulsive disorder, panic attacks, posttraumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder.[1]

Side effects of Zoloft® include dryness in the mouth, reduced appetite, nausea, sexual dysfunction, insomnia and diarrhea. In severe cases, Zoloft® can cause uncontrollable shaking and extreme mood changes including suicidal thoughts or tendencies. Suicide attempts or ideologies with Zoloft® are most common among patients under the age of 24.


Flickr: chris.corwin
Brand name for Sertraline[2]
Manufacturer Pfizer Inc.[2]
Generic available? Yes
Uses Major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), social anxiety disorder[3]
Common side effects Nausea, diarrhea, constipation, vomiting, dry mouth, gas or bloating, loss of appetite or weight changes, drowsiness, dizziness, excessive tiredness, nervousness, changes in sex drive or ability[1]
Major side effects Vision changes, seizures, fever, confusion, fast or irregular heartbeat, abnormal bleeding or bruising, hallucinations[1]
Warnings Patients who have recently had a heart attack, seizures or liver or heart disease, or who are allergic to latex (for oral solution) may be unable to take Zoloft®. Patients taking monoamine oxidase inhibitors (MAOI), pimozide (Orap), or disulfiram (Antabuse) cannot take Zoloft®. A small number of children, teenagers, and young adults experience suicidal thoughts while taking Zoloft®.[1]
Disclaimer The information provided by PharmacyDrugGuide.com is not a substitute for professional medical advice, diagnosis, or treatment. Do not take any action based on the information on this page without consulting a physician.
Author Selena Robinson


Zoloft® Overview

Zoloft® is an antidepressant used to treat several different disorders:

  • Major depression, a mood disorder in which feelings like sadness or loss interfere with everyday life for a long period of time.[1]
  • Obsessive-compulsive disorder, characterized by troublesome thoughts that persist, and the need to repeat specific actions.[1]
  • Panic disorder, in which patients experience recurrent panic attacks and may or may not suffer from agoraphobia, a fear of settings like crowds, bridges and the outdoors.[1]
  • Posttraumatic stress disorder, a condition developed after a particularly traumatic or frightening event that may involve actual or threatened death or serious injury.[1] [4]
  • Social anxiety, an extreme fear of interacting with other people that hinders normal life.[1] [4]
  • Premenstrual dysphoric disorder, which includes mood swings, irritability, bloating, and breast tenderness.[2] [3]

Zoloft® Abuse

Zoloft® is not a controlled substance and it is not commonly abused. While therapeutic doses do result in positive mood changes, large doses or doses taken by alternate methods do not seem to produce a desired effect. Zoloft® overdose may result in somnolence (drowsiness), vomiting, fast heart rate, nausea, dizziness, agitation, tremor, and death.[4]

Zoloft® Side Effects

Zoloft® has a number of common side effects. These may include:

  • Nausea or vomiting
  • Diarrhea
  • Constipation
  • Gas or bloating
  • Loss of appetite or weight changes
  • Drowsiness or excessive tiredness
  • Dizziness
  • Nervousness
  • Headache
  • Pain, burning, or tingling in the hands or feet
  • Changes in sex drive or ability
  • Excessive sweating[1]

Major side effects of Zoloft® are rare, but may require medical assistance:

  • Rash
  • Hives
  • Itching
  • Swelling of the face, throat, or tongue
  • Difficulty breathing
  • Vision changes
  • Seizures
  • Fever
  • Confusion
  • Fast or irregular heartbeat
  • Severe muscle stiffness
  • Hallucinations
  • Abnormal bleeding or bruising[1]
  • Zoloft® can cause complications if used in the final stages of pregnancy.[1]
  • Due to the possibility of drowsiness, Zoloft® patients are cautioned against operating a motor vehicle until it is clearly safe to do so on the medication.[1]

Prescription Drugs

Information on prescription drugs like Zoloft


Also See: Zoloft Side Effects, Zoloft Patient Assistance Programs, Zoloft and Pregnancy, Zoloft Free Samples, Sertraline Coupons, Lexapro, Marijuana and Prozac, Viibryd



  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 http://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0012108/?report=details
  2. 2.0 2.1 2.2 http://www.zoloft.com/
  3. 3.0 3.1 http://www.zoloft.com/about-zoloft.aspx
  4. 4.0 4.1 4.2 http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=52077